Plant medium including an oxygen-enabled composition

ABSTRACT

A composition including a plant medium and a poly-oxygenated metal hydroxide that comprises a clathrate containing oxygen gas molecules. The poly-oxygenated metal hydroxide may comprise of a poly-oxygenated aluminum hydroxide. The composition may include one or more nutrients. The composition may be in a solid form, a fluid form, or a combination thereof. The poly-oxygenated aluminum hydroxide is soluble in a fluid. In one embodiment, the poly-oxygenated metal hydroxide composition may have particles having a diameter of 212 μm or less, and which may be homogeneous.

PRIORITY

This application is a continuation of U.S. patent application U.S. Ser.No. 16/384,599 titled PLANT MEDIUM INCLUDING AN OXYGEN-ENABLEDCOMPOSITION, which is a continuation of U.S. Ser. No. 16/152,977 filedOct. 5, 2018 and issued as U.S. Pat. No. 10,272,105 titled PLANT MEDIUMINCLUDING AN OXYGEN-ENABLED COMPOSITION, the teachings of which areincorporated herein in their entirely.

TECHNICAL FIELD

The disclosure relates generally to a plant medium, such as soil, aliquid, or material including a poly-oxygenated metal hydroxidecomposition providing free oxygen for sustaining the life and growth ofthe plant.

BACKGROUND

Oxygen is one of the fundamental building blocks of life. Oxygensustains life, but it also has therapeutic (i.e. healing) powers whendelivered topically to tissue, orally for digestion, anally, vaginally,aerosolized for inhalation, injected to intramuscular tissue,intravenously to the blood circulatory system, and other deliverymethods. Conventional oxygen therapies are commonly comprised of agaseous delivery of oxygen (i.e. O₂) in chambers, such as hyperbaricoxygen therapy (HBOT). However, the concentration of oxygen delivered bygas is rather small, and the chambers are both expensive and not widelyavailable.

A poly-oxygenated metal hydroxide manufactured and marketed by Hemotek,LLC of Plano, Tex. as Ox66™, the Assignee of this application, is aclathrate containing oxygen gas molecules that has been proven to havenumerous therapeutic benefits. The Ox66™ composition is provided inpowder form and is described as a non-homogenous size particlepopulation, typically ranging from about 50 to 800 micrometers (μm).

Ox66™ exists under STP (standard temperature and pressure) as apoly-oxygenated aluminum hydroxide comprising a clathrate, and chlorine.A clathrate is a chemical substance consisting of a lattice that trapsor contains molecules. The molecules trapped or contained within theclathrate are oxygen gas (O_(2(g))). The chemical formula of theclathrate is Al₁₂H₄₂O₃₆, which mathematically is reduced to themolecular formula Al(OH)₃.6O₂. The 6 free oxygen gas molecules(O_(2(g))) are separate from the oxygen molecules covalently bound inthe hydroxide complex. The hydrogen is effervescent. The poly-oxygenatedaluminum hydroxide is soluble in a fluid.

Plants, including trees, bushes, flowers, vegetable plants and fruittrees, and so forth, all derive water, nutrients and oxygen throughtheir roots from soil or a substance proximate to their roots to sustainlife and growth. The soil or substance is referred to as a plant mediumthroughout this application. Plants can grow in soil of the earth, andare also grown in controlled environments including greenhouses andvertical farming environments. Technology has enabled a massive varietyof food, at a significantly reduced cost and with fewer resources usedfor production.

There is an increasing need to optimize and fortify plants, such as thefood supply chain to achieve more reliable, predictable, and nutritiousways to obtain basic sustenance. There is also a need to sustain thelife of plants during transfer, such as during transplantation ofplants, and also cut/grafted portions of the plants, such as movingproduce to market and cut flowers from around the world.

SUMMARY

A composition including a plant medium and a poly-oxygenated metalhydroxide that comprises a clathrate containing oxygen gas molecules.The poly-oxygenated metal hydroxide may comprise of a poly-oxygenatedaluminum hydroxide. The composition may include one or more nutrients.The composition may be in a solid form, a fluid form, or a combinationthereof. The poly-oxygenated aluminum hydroxide is soluble in a fluid.In one embodiment, the poly-oxygenated metal hydroxide composition mayhave particles having a diameter of 212 μm or less, and which may behomogeneous.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a scanning electron microscopy (SEM) image of a single 50micrometer (μm) Ox66™ particle;

FIG. 2 is a graphic art image of the jagged shaped Ox66™ particlepopulation;

FIG. 3 depicts one exemplary process used to create nano-engineeredOx66™ nanoparticles to exploit the physical and chemical properties ofeach particle-type;

FIG. 4 illustrates three different graphs modeling the effect of Ox66™particle size when varying (A) rotation rate, (B) grinding ball size,and (C) rotation time;

FIGS. 5-7 are scanning electron microscopy (SEM) images showing thenano-engineered Ox66™ particles at different image magnifications havingparticle diameters at 3 μm and below; and

FIG. 8 is a chart illustrating the filtered Ox66™ composition atdifferent particle sizes, obtained using a Scanning Electron Microscope(SEM) with Energy-dispersive X-ray spectroscopy (EDS) analyzing variousspots of the filtered Ox66™ composition;

FIGS. 9A and 9B illustrate a composition including a poly-oxygenatedaluminum hydroxide, and at least one nutrient, wherein the compositionis in a fluid form or a powder form;

FIG. 10 illustrates the solubility of the poly-oxygenated aluminumhydroxide in a fluid;

FIG. 11 illustrates a plant medium including a poly-oxygenated metalhydroxide that sustains the life and supports growth of a plant;

FIG. 12 illustrates a bush planted in a plant medium including apoly-oxygenated metal hydroxide;

FIG. 13 illustrates a tree planted in the earth including apoly-oxygenated metal hydroxide;

FIG. 14 illustrates cut flowers having flower stems disposed in a plantmedium including a poly-oxygenated metal hydroxide; and

FIG. 15 illustrates vertical farming including plants having a plantmedium disposed around the root system of the plant, such as a fluid.

DETAILED DESCRIPTION

The following description of example embodiments provides informationthat enables a person skilled in the art to make and use the subjectmatter set forth in the appended claims, but may omit certain detailsalready well-known in the art. The following detailed description is,therefore, to be taken as illustrative and not limiting. Objectives,advantages, and a preferred mode of making and using the claimed subjectmatter may be understood best by reference to the accompanying drawingsin conjunction with the following detailed description of illustrativeembodiments.

The example embodiments may also be described herein with reference tospatial relationships between various elements or to the spatialorientation of various elements depicted in the attached drawings. Ingeneral, such relationships or orientation assume a frame of referenceconsistent with or relative to a patient in a position to receivetreatment. However, as should be recognized by those skilled in the art,this frame of reference is merely a descriptive expedient rather than astrict prescription.

Nanoparticles are routinely defined as particles with sizes betweenabout 1 and 1000 nm that show physical or chemical properties that arenot found in bulk samples of the same material.

Dissolved oxygen refers to micrometer or nanometer sized bubbles ofgaseous oxygen (mixed in water or other aqueous solution) madebioavailable to organisms, animals, or humans for respiration.

Aqueous medium means pertaining to, related to, and similar to water(the most common solvent on Earth).

Particles having a diameter of less than or equal to 70 nm do not createan immune response of the mammal.

Ox66™ particles are non-toxic poly-oxygenated aluminum hydroxidecomplexes comprising a clathrate containing oxygen gas molecules, storedand solubilized in either a 1-99% by weight aqueous solution, or as adried powder, and are available from Hemotek LLC of Plano, Tex. Thematerial is non-flammable, water-soluble, and slightly basic. Particlediameter sizes typically vary between 50 and 800 μm. These particles canalso be described as a non-corrosive and non-vapor producing powder. Itsappearance is white to slightly blue as a powder with mass but verylittle weight (i.e. one gallon weighs less than 4.3 ounces), or a clearslightly viscous liquid when solubilized in an aqueous solution.

The inventive concepts disclosed and claimed in this application relategenerally to a chlorine-free poly-oxygenated aluminum hydroxidecomposition comprising a clathrate containing oxygen gas molecules thatis soluble. These chlorine-free particles have a diameter of less thanor equal to 212 μm, and enable numerous revolutionary applications andtreatments that provide significant achievements in bioscience. Throughresearch and clinical studies, these particles have been proven to treatbody conditions of mammals, including humans and animals, withastounding success and efficiency. This will be described in more detailwith respect to FIG. 8 shortly.

According to exemplary embodiments of this disclosure, through research,studies and clinical studies, it has been discovered that engineeringthe Ox66™ particles to have diameter sizes at or below 3 μm opens upsignificant and revolutionary new opportunities for oxygen therapy.Providing particles having diameters of 3 μm is critical to achievenumerous new applications, such as by oral, nasal, intravenous andtopical delivery, to treat conditions and diseases in revolutionaryways. Several of the new applications and treatments are disclosedherein.

One exemplary embodiment is delivering poly-oxygenated aluminumhydroxide particles intravenously as a resuscitative fluid, and to treatdiseases of organs when the diameter of the particles is in the range of250 nm to 1000 nm. Particles having diameters between 250 to 1000 nmwill stay in the capillary, vein, or artery linings of the circulatorysystem and not passively diffuse past the lining into surroundingtissue.

Another exemplary embodiment is delivery, by aerosol when inhaled, forabsorption of the poly-oxygenated aluminum hydroxide particles throughthe lung tissue when the particles are reduced to 250 nm and less. Suchan application effectively treats internal burns. Particles having adiameter size from 1 to 3000 nm deposit into the deep airway ducts anddiffuse evenly within the alveolar or gas exchange regions of the lung.

A remarkable example is delivering the poly-oxygenated aluminumhydroxide particles intravenously to treat traumatic brain injury (TBI)when the diameter of the particles is reduced to about 300 nm and lessso that the particles can traverse the brood brain barrier (BBB). Thisapplication can also be used to treat strokes, chronic traumaticencephelopathy (CTE), and perhaps even cancer.

There is a significant biophysical difference between a 50 μm particleand a 3 μm particle. After intravenous administration, 50 μm particlesare larger and have more mass than 3 μm particles, therefore they tendto absorb onto the linings of the veins. Three (3) μm particles stay incirculation much longer, have much less mass, and have higher surfacearea. After inhalation administration, 50 μm diameter particles depositin the oral or nasal cavity and do not reach even the upper airways ofthe lung. Three (3) μm diameter particles are small enough to deposit inthe very deep lung and perfuse out to the lung lining. After topicaladministration, 50 μm diameter particles tend to stay on the surface ofthe epidermis and eventually wash off the skin completely. Three (3) μmdiameter particles penetrate through the epidermis and dermis layers ofthe skin and reside in the subcutaneous layer of the skin. After oraladministration, 3 μm diameter particles absorb through the lining of theesophagus and stomach. Fifty (50) μm diameter particles reside in thestomach for up to 4 hours, dissolve (or break-down) and lose theiroxygen carrying capability.

Another exemplary embodiment includes increasing the oxygen content offluids with nanometer-sized Ox66™ particles, such as water, sportsdrinks, and nutritional drinks, which provides many benefits andapplications. The nanometer-sized Ox66™ particles have been clinicallyshown to pass through the stomach, duodenum, and intestinal walls intothe bloodstream of the body, and are not simply absorbed by the stomachlining. One method for increasing the dissolved oxygen content in anaqueous medium includes sparging the aqueous medium with air, oxygen oroxygen-enriched air.

In another exemplary embodiment, the nanometer-sized Ox66™ particles,either as a powder or in a carrier such as a gel or lotion, have alsobeen clinically proven to increase the level of localized oxygen ininjured tissues to accelerate the healing process.

FIG. 1 is a scanning electron microscopy (SEM) image of a single 50micrometer (μm) Ox66™ particle. A 50 μm particle is easily aerosolized,but it is well outside the respirable range of 1-3 μm. A 50 μm particlehas little density due to its chemical composition and its porosity.FIG. 2 is a graphic art image of the jagged shaped Ox66™ particlepopulation.

Controlled milling is defined as a machining procedure using vesselsaccelerating in a rotary or planetary motion to decrease the size of theprimary particles from micrometer sized to nanometer sized materials.Milling covers a wide array of procedures, operations, tools, andmachines. The resultant nanometer sized particle can be accomplishedusing small instruments or large milling machines. Example millinginstruments include: “milling machine”, “machining centers”, or“multitasking machines”.

Referring to FIG. 3, there is shown an exemplary process shown at 40 forforming nanosized Ox66™ particles having diameter sizes of 3 μm or lessusing a planetary motion milling machine.

At step 42, a predetermined quantity of the quality assured Ox66™powdered material is measured, and placed in a container.

At step 44, a milling scale is used to establish parameters of thegenerating particles having a diameter of 3 μm or less, such as shown inFIG. 5, both for small-scale production as well as mass production. Themilling procedure is dependent upon the features of the ball mill, whichmay be a planetary motion device, such as Retsch Planetary Ball Mill PM100, 200, or 400 or United Nuclear Scientific Equipment ‘Hobby’ BallMill. The milling procedure identifies several variables, including aquantity of Ox66™ material, the rotation rate, the size of the millingbeads, the type of milling beads, and the time of milling to achievedesired size of the Ox66™ particles. For example, the rotation rate maybe for at least 1 minute up to 1,440 minutes at a rotation rate of atleast 100 up to 10,000 rotations per minute.

FIG. 4 includes three different graphs modeling the effect of Ox66™particle size when varying (A) rotation rate, (B) grinding ball size,and (C) rotation time. As rotation rate, measured in rotations perminute (rpm) increases, particle size decreases. As grinding ball size,measured in millimeters (mm) decreases, particle size decreases. Asrotation time, measured in hours (hrs) increases, particle sizedecreases.

At step 46, the predetermined quantity of Ox66™ particles are thenmilled in a controlled manner in a planetary motion ball mill, accordingto the milling procedure to achieve a desired homogenous size of theOx66™ particles. The Ox66™ particles are milled or ground down underhigh energy in the presence of a milling media, such as highlyreticulated polystyrene or zirconium milling beads. The Ox66™ particlesare recirculated, re-milling them until a consistent product isgenerated.

Optionally, at step 48, additional sorting may be performed.

At step 50, the homogeneous milled Ox66™ particles are subjected toquality analysis to confirm sizing and consistency. If the Ox66™particles are not consistent, they may be further milled to achieve thedesired sizing.

The milling media can also abrade under the conditions of milling, socare is taken such that significant contamination of the nanosuspensionby the milling media does not occur. Nanosuspension is defined as asubmicron colloidal dispersion of drug particles.

The resultant Ox66™ particles have a primary particle size of 3 μm orless. In one exemplary embodiment, the reduced size particles are thenseparated into homogeneous sizes in an effort to exploit the physicaland chemical properties of each particle-type. Sieves can be used tosort out particles by sizes to create homogenous sizes of particles,such as sieve shakers manufactured by Endecotts Ltd of London, UK.Different size sieve filters are used to obtain selected particle sizes.

One homogenous size of particles may be particularly beneficial fortreating a particular body condition, such as 300 nm (or less) diameterparticles to treat traumatic brain injury (TBI). Another homogenous sizeof particles may be beneficial for providing a resuscitative fluid (RF)to increase the tissue oxygenation (PO₂), such as using 2 μm-4 μmdiameter particles which do not trigger an immune response. Generatingnanometer sized particles increases the in vivo (i.e. in a whole, aliveorganism) dissolution rate and fraction absorbed to increases oralbioavailability.

FIGS. 5-7 are scanning electron microscopy (SEM) images showing thenano-engineered Ox66™ particles at different image magnifications,showing the particle diameters at 3 μm and below.

The pharmaceutical preparation of nanomaterial-based dosage forms isencouraged by a number of pharmaceutical drivers; for compounds whosewater solubility or dissolution rate limits their oral bioavailability,size reduction into the nanometer size domain can increase in vivodissolution rate and fraction absorbed.

The process to generate a homogeneous nanometer size particle populationcan also be of use in the design of parenteral dosage forms whereinpoorly soluble drugs can be “milled” to a specified size and size rangeresulting in not only useful bioavailability but also sustained releasefeatures.

The development of drug particles within the nanometer size regime of 1to 1000 nm involves a top-down approach in which the active ingredientis milled (or otherwise subjected to particle reduction strategies) ineither an aqueous environment or in a dry formulation; top-downstrategies are considered more controllable and more robust as afunction of process and design space for this type of manipulation.

DESCRIPTION OF EXAMPLE EMBODIMENTS

Chlorine-Free Poly-Oxygenated Aluminum Hydroxide

Referring now to FIG. 8, according to another embodiment of thisdisclosure, a composition of chlorine-free poly-oxygenated metalhydroxide comprises a clathrate containing oxygen gas molecules. Thecomposition is soluble.

The chlorine-free poly-oxygenated metal hydroxide composition isbeneficial in a therapeutic quantity when delivered to a mammal,including, but not limited to, oral, topical, nasal, vaginal, anal, andintravenously administration. The composition is poly-oxygenated becauseit has oxygen gas (O_(2(g))) that is free to move in the compositionmolecules, and which oxygen gas is bioavailable to oxygenate the mammal.

In one exemplary embodiment, the chlorine-free poly-oxygenated metalhydroxide is a composition of filtered poly-oxygenated aluminumhydroxide Ox66™ composition. The poly-oxygenated aluminum hydroxidecomposition is free of chlorine residuals and may be homogeneous.Homogeneous as used in this application means that the sizes of theparticles fall in a tight range of sizes, such as between 107-212 um,46-106 um, and 26-45 um. It has been discovered that Ox66™ particleshaving a diameter of less than or equal to about 212 um are free ofchlorine residuals and particles. Applicant sorted the Ox66™ compositionby size into batches, and discovered that filtered particles having adiameter less than about 212 um had a noticeably different texture andfeel. Upon further investigating using a calibrated Scanning ElectronMicroscope (SEM) laboratory instrument to analyze various spots of thecomposition for different size ranges, it was discovered that suchparticles under 212 um were free of chlorine particles and residuals, assupported in the test results shown in FIG. 8.

FIG. 8 illustrates the composition of filtered Ox66™ at differentparticle sizes, where there is shown five tables, obtained using aScanning Electron Microscope (SEM) with Energy-dispersive X-rayspectroscopy (EDS).

As shown in the bottom table in FIG. 8, the data obtained from analyzingfour (4) spots of the Ox66™ composition in a batch of homogeneous Ox66™particles each having a diameter between 426-500 um is shown. The firstspot reflects analyzing the substrate having carbon. The data fromanalyzing the other 3 spots shows the percentage of chlorine varyingbetween 14.67% and 45.52%, which is very significant. It is noted thedetected carbon component in some samples is part of the substrate mediathat the composition is prepared upon during testing, and the carbon isnot part of the composition itself.

As shown in the table second from the bottom of FIG. 8, the dataobtained from analyzing four (4) spots of the Ox66™ composition in abatch of homogeneous Ox66™ particles having a diameter between 300-425um is shown. The data from analyzing the 4 spots shows the percentage ofchlorine varying between 15.46% and 16.85%. These are significantpercentages of chlorine, and the chlorine is undesirable in manyproducts, treatments and therapies as they can create adverse resultsand reactions.

As shown in the three upper tables in FIG. 8, the data obtained fromanalyzing spots of the Ox66™ composition in different batches of Ox66™particles having a diameter of less than 212 um shows the composition isentirely free of chlorine in all spots. This is true for the batches ofhomogeneous Ox66™ particles having a diameter between 26-45 um, 46-106um, and 107-212 um, as shown. This is significant and highly beneficialas previously described.

The composition comprising chlorine-free particles having diameterssized at or below 212 um have tremendous uses in products, treatmentsand therapies. For instance, the chlorine free composition is not adesiccant, which makes it ideal in some products, including cosmeticswhere maintaining moisture is preferred. A desiccant is a hygroscopicsubstance that induces or sustains a state of dryness (desiccation) inits vicinity. Commonly encountered pre-packaged desiccants are solidsthat absorb water. Chlorine is fairly reactive with water and oxygen andacts as a desiccant in particle systems. The Ox66™ composition is often,but not always, better suited when chlorine is absent in the formulationbecause of the desire to maximize the amount of oxygen in the product toimprove efficacy. Cosmetic products including creams, moisturizers,serums, etc. tremendously benefit from the oxygen carrying properties ofthe Ox66™ composition, as well as the chlorine free composition of thisdisclosure.

It is noted that for larger particle suspensions in water, chlorine maybe desired for stability, and for certain uses where chlorine is abenefit, such as when used as a desiccant.

A formulation without chlorine is a more simple and streamlined compoundthat saves time, money, and resources. A quantity of such chlorine-freeparticles has a softer feel and is less abrasive than the compositionincluding chlorine, making the composition suitable for cosmetics thathave demanding requirements from both manufacturers and customers.

Using the electron mapping analytical technique, it was determined thatOx66™ contains very few elements from the periodic table. These elementsinclude aluminum (Al), hydrogen (H), and oxygen (O), and chlorine (Cl).On Earth, the most stable material that includes the first of thesethree elements is commonly referred to as “aluminum hydroxide”. And themost stable aluminum hydroxide chemical formula is Al(OH)₃. The aluminumhydroxide is seen as a clathrate including free oxygen gas O₂, and thechlorine is a separate particle.

A chemical formula is an expression which states the number and type ofatoms present in a molecule of a substance.

After further analytical analyses using energy dispersive X-rayspectroscopy on the aluminum hydroxide clathrate, it was subsequentlydeduced that the balanced mass ratio (at the elemental level) of thealuminum hydroxide portion of Ox66™ includes 12 aluminum (Al) atoms, 42hydrogen (H) atoms, and 36 oxygen (O) atoms. Simply put, this chemicalformula is represented as is Al₁₂H₄₂O₃₆.

The relationship between Al(OH)₃ and Al₂H₄₂O₃₆ is substantiated whenadditional analytical techniques confirm the presence or absence ofother stable molecules associate with the Ox66™ material. These othermolecules include H₂, O₂, and H₂O. There is strong evidence thatsupports that O₂ gas is present—and that the quantity of the moleculesis approximately 6:1 in ratio of O₂:Al(OH)₃. There is no evidence tosuggest that the Ox66™ material includes H₂ or H₂O molecules in itssystem.

Hydrogen (H) atoms, when combined in their simplest configuration, formshydrogen gas (H₂). These molecules are effervescent and have thepotential to evacuate the aluminum hydroxide Ox66™ clathrate structurevery easily since H₂ molecules are very small. In fact, the diameter ofa hydrogen gas molecule is smaller than the estimated pore size of thealuminum hydroxide Ox66™ clathrate structure.

Since there is no evidence that water (H₂O) molecules are present in theOx66™ material structure, and because there is no evidence that oxygen(O₂) gas is present, it is extrapolated that the Ox66™ chemical formulaAl₁₂H₄₂O₃₆ re-arranged to a molecular formula Al₁₂(OH)₃₆ with ˜6 oxygengas molecules present and ˜12 hydrogen gas molecules escaped.

Molecular formula is a formula giving the number of atoms of each of theelements present in one molecule of a specific compound.

The reduced molecular formula can be hypothesized and represented asAl(OH)₃.6O₂.

FIG. 10 illustrates the solubility of the Ox66™ poly-oxygenated aluminumhydroxide in a fluid. As shown, the Ox66™ composition is soluble in afluid up to 1 gram of Ox66™ composition per 100 ml of a fluid, such aswater, (1 g/100 ml.).

Nutraceuticals

In one exemplary embodiment, the chlorine-free poly-oxygenated aluminumhydroxide composition is particularly well suited for use with or innutraceuticals, including products configured to be orally ingested by amammal. FIGS. 9A and 9B illustrate a composition including apoly-oxygenated aluminum hydroxide, such as the soluble poly-oxygenatedaluminum hydroxide clathrate portion of the Ox66™ composition, and atleast one nutrient, wherein the composition in a fluid form as shown inFIG. 9A, or in a powder form as shown in FIG. 9B.

A nutraceutical is defined as a pharmaceutical-grade and standardizednutrient. Such nutraceuticals include proteins, vitamins, fiber, andelectrolytes that can be found in baby formula, health bars, andsupplements, such as Similac®, PediaSure®, Pedialyte®, Glucerna®, andEnsure® products manufactured by Abbott Labs of Abbot Park, Ill., eachof which is a U.S. Registered trademarks of Abbott Labs, Gerber® GoodStart® products and Boost® products each manufactured by Nestle® ofSwitzerland. Other nutraceuticals can include, but are not limited to,performance enhancing products including Gatorade® branded productsincluding fluids, powders, and bars.

One embodiment of an electrolyte nutraceutical configured to treatdehydration comprises a solution having a balance of sugar,electrolytes, and the Ox66™ composition providing oxygen gas containedin the clathrate. This nutraceutical is formulated with an optimalbalance of sugar and electrolytes needed to help replenish vital fluids,minerals, and nutrients in the body, which, when lost, can lead todehydration. The oxygen gas of the Ox66™ composition helps to oxygenatethe human body which improves body function.

When the electrolyte nutraceutical is used as a treatment for hangovers,the oxygen gas helps speed up the breakdown of alcohol. Once absorbed bythe bloodstream, the alcohol leaves the body in three ways: The kidneyeliminates 5 percent of alcohol in the urine; the lungs exhale 5 percentof alcohol, which can be detected by breathalyzer devices; and the liverchemically breaks down the remaining alcohol into acetic acid.

The breakdown, or oxidation, of alcohol occurs in the liver, wherein anenzyme in the liver called alcohol dehydrogenase strips electrons fromalcohol to form acetaldehyde. Another enzyme, called aldehydedehydrogenase, converts the acetaldehyde, in the presence of oxygen, toacetic acid, the main component in vinegar. When the alcohol is oxidizedto acetic acid, two protons and two electrons are also produced. Theacetic acid can be further broken down into carbon dioxide and water.

As a rule of thumb, an average person can normally eliminate 0.5 oz (15ml) of alcohol per hour. So typically, it would take approximately onehour to eliminate the alcohol from a 12 oz (355 ml) can of beer.

Advantageously, by consuming the electrolyte nutraceutical including theOx66™ composition, the oxidizing and breakdown of the alcohol isaccelerated in the human body due to the oxygen gas released by theclathrate into the bloodstream, thus reducing the time for the body tobreakdown alcohol, and thus reducing the experienced effects of alcoholincluding intoxication, and the unwanted effects of hangovers.

In one exemplary embodiment, 1 mg of the Ox66™ composition is mixed withabout 12 oz (355 ml) of a balanced sugar and electrolyte solution suchas shown in FIG. 9A, although different ratios of this mix areacceptable. It is preferable to use the Ox66™ composition havingparticles each with a diameter of under 212 um as this embodiment doesnot include chlorine as previously described. An example is adding 4 mgof the Ox66™ composition with particles each having a diameter under 212um to 33.8 oz (1 liter) of Pedialyte® Oral Electrolyte. Otherembodiments include adding the Ox66™ composition with particles eachhaving a diameter under 212 um to Pedialyte® kids and adult powder, andPedialyte® freezer pops.

Another illustrative embodiment of a nutritional configured to ensure ahealthy digestive system comprises one or more of a protein, vitamins,minerals, fiber, in addition to the Ox66™ composition. In oneillustrative embodiment, 1 mg of the Ox66™ composition with particleseach having a diameter under 212 um is added to 7 g protein and 25vitamins and minerals, as well as 3 g fiber. One illustrative embodimentcomprises adding 1 mg of the Ox66™ composition with particles eachhaving a diameter under 212 um to an 8 fluid ounce (236 ml) ofPediaSure® Grow and Gain with Fiber. The addition of the Ox66™composition provides the additional benefit of free oxygen gas moleculesthat are beneficial to the digestive system of a mammal. It has beenclinically proven at Baylor University in Waco, Tex. that the Ox66™composition is absorbed into the body bloodstream through the stomachlining, and in addition, is passed into the upper intestine of thedigestive system. The free oxygen gas molecules of the Ox66™ compositionare advantageous to increase oxygen throughout the body.

In another embodiment, the Ox66™ composition with particles each havinga diameter under 212 um is added to Ensure® branded adult products.Examples include Ensure® Original, Ensure® Plus, Ensure® Enlive, Ensure®High Protein, Ensure® Clear, and Ensure® Light. The Ox66™ composition isabsorbed into the body bloodstream through the esophagus and stomachlining, and in addition, is passed into the upper intestine of thedigestive system. The free oxygen gas molecules of the Ox66™ compositionare advantageous to increase oxygen throughout the body. Oneillustrative embodiment comprises adding 1 mg of the Ox66™ compositionwith particles each having a diameter under 212 um to an 8 fluid ounce(236 ml) of Ensure® Enlive.

In another embodiment, the Ox66™ composition with particles each havinga diameter under 212 um is added to Similac® branded or Gerber® GoodStart® branded products for babies, toddlers, and nursing mothers.Illustrative examples include Similac® Pro-Advance, Similac® AdvanceNon-GMO, Similac® Advance, Similac® for Supplementation NON-GMO,Similac® Organic, and Similac® Pure Bliss infant formula. Oneillustrative embodiment comprises adding 1 mg of the Ox66™ compositionwith particles each having a diameter under 212 um to an 8 fluid ounce(236 ml) of a Similac branded product. The Ox66™ composition withparticles each having a diameter under 212 um can also be mixed with thecommercial powered versions of the products such as Similac Pro-Advance,as shown in FIG. 9B.

In another embodiment, the Ox66™ composition with particles each havinga diameter under 212 um is added to Glucerna® branded products suitablefor individuals with diabetes. One illustrative embodiment comprisesadding 500 mg/ml of the Ox66™ composition with particles each having adiameter under 212 um to an 8 fluid ounce (236 ml) of a Glucerna®branded product, such as Glucerna® Snack Shakes, Glucerna® Hunger SmartNutrition Shakes, and Glucerna® Therapeutic Oral Supplement. The Ox66™composition with particles each having a diameter under 212 um can alsobe added to solid foods, such as Glucerna® Nutrition bars.

In another embodiment, products manufactured by Nestle® of Switzerlandincluding the Boost® branded nutritional products are supplemented withthe Ox66™ composition with particles each having a diameter under 212um. As with the Abbot Labs® suite of products, one illustrativeembodiment comprises adding 500 mg/ml of the Ox66™ composition withparticles each having a diameter under 212 um to an 8 fluid ounce (236ml) of a Boost® branded product, such as Boost® Original, Boost® HighProtein, Boost® Glucose Control, Boost® Plus, and Boost® Calorie Smart.Some of these Boost® nutritional products are available in powders. TheOx66™ composition is mixed with the powder in proportion such that 500mg/ml of the Ox66™ composition with particles each having a diameterunder 212 um is provided in an 8 fluid ounce (236 ml) portion.

In another embodiment, nutritional products manufactured by Gatorade® ofChicago Ill., including Gatorade Recover® products including proteinshakes, are supplemented with the Ox66™ composition with particles eachhaving a diameter under 212 um. One illustrative embodiment comprisesadding up to 500 mg/ml of the Ox66™ composition with particles eachhaving a diameter under 212 um to an 8 fluid ounce (236 ml) of aGatorade Recover® branded product.

In each of the embodiments of a composition described above comprising anutraceutical and the Ox66™ composition with particles each having adiameter under 212 um, a preferred concentration is at least 1 milligramof the Ox66″ composition for every 8 fluid ounces of fluid, and up to500 mg/ml.

IV Delivery

In one exemplary embodiment, the chlorine-free composition is alsoparticularly well suited as a poly-oxygenated metal hydroxide that isintravenously (IV) deliverable to a mammal. Such IV deliverable productscan include 75-90% colloid or crystalline solution with 10-25% additionof poly-oxygenated metal hydroxide particles. The poly-oxygenated metalhydroxide may have a concentration range of 0.1 mg/l to 1000 mg/l. Thepoly-oxygenated metal hydroxide may have particles that are surfacemodified.

In one example method of use, the chlorine-free composition istherapeutically beneficial to treat a depletion of hemoglobin in themammal, wherein the poly-oxygenated metal hydroxide acts as an oxygenresuscitative fluid to treat hypoxia, increasing the interstitial tissueoxygenation P_(ISF) O₂.

In other exemplary embodiments, products may include the chlorine-freecomposition in wound care, hair care, and skin care products. Such woundcare products are configured to promote and accelerate the healing ofskin wounds and lesions. Hair care products include products configuredto reduce baldness and re-grow hair, as the bioavailable oxygen gas isbeneficial to stimulate growth of hair follicles which may be oxygendeprived, and hair dyes. Skin care products can include lotions, gelsand soaps, for example, that treat skin conditions, such as psoriasisand eczema.

The Ox66™ composition is:

configured to be therapeutically effective in treating a condition of amammal; configured to be intravenously delivered to a mammal, such as tooxygenate the mammal; configured to not create an immune response of themammal;

configured to penetrate through epidermis and dermis layers of skin andreside in a subcutaneous layer of the skin;

configured to absorb through lining of an esophagus, a stomach and asmall intestine;

configured to traverse a brood brain barrier (BBB) of a mammal; and

configured to stay in a capillary, vein, or artery linings of a mammalcirculatory system and not passively diffuse past a lining intosurrounding tissue.

Plant Medium

An illustrative embodiment of a plant medium 100 including apoly-oxygenated metal hydroxide is shown in FIG. 11, such as comprisingOx66™. The plant medium may be in a solid form, a fluid form, or acomposition thereof, such as a gel or paste. Examples of a solid forminclude soil, dirt, sand, compost, a synthetic substance, a filler, justto name a few. Examples of a fluid form include a liquid, gas, gel, andsolution comprised of two or more substances.

In one embodiment, a plant 102 is planted in the plant medium 100including a poly-oxygenated metal hydroxide, such as Ox66™, as shown inFIG. 12. A plant is defined in this application as a living organism ofthe kind exemplified by trees, shrubs, herbs, grasses, ferns, andmosses, typically growing in a permanent site, absorbing water andinorganic substances through its roots, and synthesizing nutrients inits leaves by photosynthesis using the green pigment chlorophyll. FIG.12 illustrates a bush planted in a receptacle 104 containing a quantityof the plant medium 100 mixed with a quantity of the poly-oxygenatedmetal hydroxide, having the freely available O₂. This freely availableO₂ helps the plant grow faster and healthier, and may help resistdisease. For instance, 1 cubic ft. of the plant medium comprising soilis mixed with 2 ounces of the poly-oxygenated metal hydroxide, althoughother concentrations are within the scope of this disclosure. All theplant medium in the receptacle can be thoroughly mixed with thepoly-oxygenated metal hydroxide, or just a subpart thereof. Forinstance, only the plant medium proximate and about the roots of theplant can be mixed with poly-oxygenated metal hydroxide, and/or thesurface of the plant medium. The plant medium can include at least onenutrient, such as a fertilizer comprises of nitrogen and phosphorus, ina liquid or solid form, such as granules.

The plant medium can also include a fluid comprising a solutionincluding a liquid and the poly-oxygenated metal hydroxide, and at leastone nutrient. For instance, a solution having a concentration of atleast 1 milligram of the poly-oxygenated metal hydroxide to 8 fluidounces of a fluid, such as water, and a nutrient. In one embodiment, thepoly-oxygenated metal hydroxide can be completely solubilized in thefluid, and in another embodiment only a portion of the poly-oxygenatedmetal hydroxide is solubilized in the fluid. As shown in FIG. 10 andpreviously discussed, the poly-oxygenated metal hydroxide is soluble upto 1 gram per 100 mL of fluid.

The particle sizes of the poly-oxygenated metal hydroxide used in theplant medium can be of any size in one embodiment. In anotherembodiment, the poly-oxygenated metal hydroxide can be comprised ofparticles having a size at or below 212 um so that there is no chlorinein the poly-oxygenated metal hydroxide. The poly-oxygenated metalhydroxide may be homogenous in an embodiment.

As shown in FIG. 13, a plant planted in the earth has thepoly-oxygenated metal hydroxide distributed on top of the soil about theplant, or within an upper portion of the soil about the plant. FIG. 13illustrates a tree 106 planted in the earth 108, where the plant mediumdisposed about the roots 110 of the plant is mixed with thepoly-oxygenated metal hydroxide. The plant can also be watered with thefluid comprising the poly-oxygenated metal hydroxide. The roots canabsorb the oxygen gas O₂ in the poly-oxygenated metal hydroxide and thusthe plant grows vigorously and better sustains life. Fruit and flowerson the tree grow better in terms of quality, and quantity due to thereadily available oxygen gas absorbed the tree roots. Watering of thetree can help improve the intake of the oxygen gas freely available O₂in the plant roots, in part because the poly-oxygenated metal hydroxideis soluble in the water and better distributes about the root system.

FIG. 14 shows an embodiment illustrating multiple flowers 120 cut from abush or tree, with the cut ends of the flower stems enveloped with theplant medium 100 including the poly-oxygenated metal hydroxide within avessel 122. For instance, a liquid such as water includes thesolubilized poly-oxygenated metal hydroxide such that the flower stemsabsorb the freely available oxygen gas and the flowers remain healthyand fresh a longer period of time, such as up to 2 weeks or more. Theflower industry is huge, and flowers are cut and shipped all around theworld. The plant medium including the poly-oxygenated metal hydroxidehelps the flowers survive during both transport, and after delivery to acustomer. A vase can be used by a customer to display the flowers andcontain the plant medium. The plant medium can be distributed as apacket by a florist, and the plant medium added to tap water.Considering cut flowers have different survival times, by extending thetime flowers remain healthy and beautiful can increase flower sales, andalso allow the transportation of flowers that otherwise would notsurvive the transportation and be marketable to consumers. For instance,unique flowers from remote parts of the earth can't survive multipleflights and extended shipment times to market. Using the plant mediumaccording to this disclosure allows these unique flowers to survive andbe marketed globally. The poly-oxygenated metal hydroxide can also helpthe flowers survive varying and extreme temperatures.

Illustrative Example

On day 0, two like sets of a dozen red roses of were placed in identicalvases with the same amount of water on a table proximate each other, andsubject to the same ambient conditions. One set was given only the foodthat came in a typical florist packet, and the other was given the samefood that came in the packet, but in addition, one heaping tablespoon ofthe poly-oxygenated metal hydroxide. These typical florist packetstypically contain three ingredients: citric acid, sugar, and bleach.Plants do produce sugar during photosynthesis, but when they're cut, soare their food pipelines. Since flowers can be collected before they'vefully developed, they need a little food to bolster their buds. Nothingwas added to the water of each vase after day 0.

On day 3, the set of rose flowers with only the food packet showedslight signs of wilting, while the set of rose flowers with the foodpacket and the poly-oxygenated metal hydroxide looked generallyunchanged.

On day 6, the vase of rose flowers with only the food packet showed moresigns of wilting, and some rose heads were partially drooped. However,the vase with the set of rose flowers with the food packet and also thepoly-oxygenated metal hydroxide showed minimal signs of wilting, and norose heads were drooping.

On day 9, all but one rose head in the vase with only the food packetwere mostly or completely drooping. Noticeably, all the rose heads inthe set of flowers with the food packet and the poly-oxygenated metalhydroxide showed only marginal wilting and no drooping rose heads. Also,on day 9, the water in the vase with only the food packet was slightlycloudy, while the water in the vase with the set of flowers with thefood packet and the poly-oxygenated metal hydroxide was completelyclear. This clear water illustrates that the poly-oxygenated metalhydroxide reduces the decomposition of the cut end of the rose stems,and thus the cut end of the stems are still healthy and able to pass theoxygen gas to the stem to extend the longevity of the rose.

On day 12, all rose heads were completely drooping and expired in thevase with only the food packet. Remarkably, the rose heads were onlymoderately wilting, with only 1 completely drooping head and a fewmoderately drooping heads, in the vase with the set of flowers with thefood packet and the poly-oxygenated metal hydroxide. Several rose headsstill had a straight stem, which is significant for flowers,particularly roses.

As illustrated in FIG. 15, vertical farming can include thepoly-oxygenated metal hydroxide in the plant medium 100 disposed aboutthe roots of the plants 102 where the poly-oxygenated metal hydroxide isfed to the plant roots via a fluid. Each of the plants 102 have theirroots supplemented with the plant medium, such as in soil disposed aboutthe roots, or in a nutrient-filled fluid, such as water, communicatedvia a distribution system and fed to the roots, and a combinationthereof. Support ladders or structure 122 support each of the plants102, where the structure 122 can be used to support a fluid deliverysystem 124 to distribute the plant medium as a fluid via conduits to theplant roots. The plant medium can comprise of synthetic or organicmaterial. A structure 122 may have holes allowing the plants to growtherethrough, and/or attach thereto, and support the plants. Thestructure 122 itself may include the poly-oxygenated metal hydroxide,such as being dispersed in the structure. The plant medium can be aslurry or loose paste in some embodiments. One illustrative example ofvertical farming is the system of Eden Green of Cleburne, Tex. Accordingto this disclosure, the nutrient-filled water includes thepoly-oxygenated metal hydroxide, and the growth time of plants isreduced, which thus increases the yield of the vertical farm per year.

The appended claims set forth novel and inventive aspects of the subjectmatter described above, but the claims may also encompass additionalsubject matter not specifically recited in detail. For example, certainfeatures, elements, or aspects may be omitted from the claims if notnecessary to distinguish the novel and inventive features from what isalready known to a person having ordinary skill in the art. Features,elements, and aspects described herein may also be combined or replacedby alternative features serving the same, equivalent, or similar purposewithout departing from the scope of the invention defined by theappended claims.

What is claimed is:
 1. A combination, comprising: a support, a plant;and a poly-oxygenated aluminum hydroxide composition comprising aclathrate containing oxygen gas molecules disposed about the plant,wherein the poly-oxygenated aluminum hydroxide composition provides freeoxygen for sustaining the life and growth of the plant.
 2. Thecombination as specified in claim 1, further comprising a plant mediumdisposed about a portion of the plant, wherein the poly-oxygenatedaluminum hydroxide composition is disposed in the plant medium.
 3. Thecombination as specified in claim 2, wherein the plant medium comprisessoil.
 4. The combination as specified in claim 2, wherein the plantmedium comprises a fluid.
 5. The combination as specified in claim 2,wherein the plant medium comprises a nutrient.
 6. The combination asspecified in claim 2, wherein the portion of the plant comprises rootsof the plant.
 7. The combination as specified in claim 1, where thepoly-oxygenated aluminum hydroxide composition is soluble.
 8. Thecombination as specified in claim 1, wherein the poly-oxygenatedaluminum hydroxide composition is chlorine-free.
 9. A method of treatinga plant coupled to a support, comprising: delivering a poly-oxygenatedaluminum hydroxide composition comprising a clathrate containing oxygengas molecules to a portion of the plant, wherein the poly-oxygenatedaluminum hydroxide composition provides free oxygen for sustaining thelife and growth of the plant.
 10. The method as specified in claim 9,wherein the of oxygenated aluminum hydroxide composition is disposed ina plant medium.
 11. The method as specified in claim 10, wherein theplant medium includes a nutrient.
 12. The method as specified in claim10, wherein the plant medium comprises soil.
 13. The method as specifiedin claim 10, wherein the plant medium comprises a fluid.
 14. The methodas specified in claim 9, wherein the poly-oxygenated aluminum hydroxidecomposition is soluble.
 15. The method as specified in claim 9, whereinthe poly-oxygenated aluminum hydroxide composition is chlorine-free. 16.The method as specified in claim 9, wherein the portion of the plantcomprises roots of the plant.